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Ciproxifan maleate

SIGMA/C6848 - ≥98% (HPLC), powder

Synonym: Cyclopropyl (4-[3-(1H-imidazol-4-yl)propyloxy]phenyl) ketone maleate salt; FUB 359 maleate salt

CAS Number: 184025-19-2
Empirical Formula (Hill Notation): C16H18N2O2 · C4H4O4
Molecular Weight: 386.40
MDL Number: MFCD06411563
Linear Formula: C16H18N2O2 · C4H4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C6848-5MG 5 mg
 $184.00
1/EA		 Add To Favorites
45-C6848-25MG 25 mg
 $640.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C16H18N2O2.C4H4O4/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;5-3(6)1-2-4(7)8/h5-8,10-12H,1-4,9H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key RLQFKEYRALXXEJ-BTJKTKAUSA-N
Quality Level 100 
SMILES string OC(=O)C=C/C(O)=O.O=C(C1CC1)c2ccc(OCCCc3c[nH]cn3)cc2
solubility DMSO: 32 mg/mL
  H2O: insoluble
Application: Ciproxifan maleate has been used as a selective H3R antagonist to investigate the antidepressant potential of ciproxifan in chronic unpredictable stress (CUS) model of depression in mice. It has also been used as an H3R antagonist to develop in vivo receptor occupancy assay for histamine H3 receptors (H3R)/to determine the occupancy of exogenous H3R antagonists using non-radiolabeled GSK189254 as a tracer in the rat.
Biochem/physiol Actions: Cyclopropyl 4-(3-(1H-imidazol-4-yl)propyloxy)phenyl methanone (Ciproxifan) is a species-specific histamine H3 receptor (H3R) inverse agonist. It is mainly used as a reference H3R antagonist in rodent models for neurological diseases, Alzheimer′s disease, attention deficit hyperactivity disorder (ADHD), and sleep-wake disorders. It can block monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) enzyme isoforms reversibly in humans and rats.
Biochem/physiol Actions: Potent, selective H3 histamine receptor antagonist.
Features and Benefits: This compound is featured on the Histamine Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
UNSPSC 12352200

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