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5-Chloro-2′-deoxyuridine

SIGMA/C6891 - thymidine analog

Synonym: CldU

CAS Number: 50-90-8
Empirical Formula (Hill Notation): C9H11ClN2O5
Molecular Weight: 262.65
MDL Number: MFCD00006531
Linear Formula: C9H11ClN2O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C6891-100MG 100 mg
 $103.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C6891-100MG

 

assay ≥98% (HPLC)
form powder
InChI 1S/C9H11ClN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI key NJCXGFKPQSFZIB-RRKCRQDMSA-N
Quality Level 100 
SMILES string OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(Cl)C(=O)NC2=O
solubility 1 M NH4OH: 20 mg/mL, clear, colorless to faintly yellow
storage temp. −20°C
Application: 5-Chloro-2′-deoxyuridine has been used to:
• study cell cycle dynamics by immunohistochemical analysis and double S-phase labeling using animal models
• analyze cell cycle length using an animal model
• label HEK293T cells for molecular combing assay
Biochem/physiol Actions: DNA labeled with 5-chloro-2′-deoxyuridine (CldU) serves as an effective tool to analyze and quantify DNA replication, repair, and recombination. CldU is a potent mutagen, clastogen, and toxicant. It is used as a thymidine analog and is found to alter the dNTP pools and might lead to cell-cycle arrest. CldU produces sister-chromatid exchange but has less response to ionizing radiation compared to other thymine analogs. 5-Chloro-2′-deoxyuridine (CldU) is used to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors. When used with antibody based immunofluorescent imaging, 5-Chloro-2′-deoxyuridine incorporation may be used in protocols to identify sites of DNA replication. CldU may be used as a labeling substrate in conjunction with other halogenated uridine labeling substrates such as iododeoxyuridine (IdU).
Packaging: 100 mg in poly bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 41106305

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