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WY-14643

SIGMA/C7081

Synonym: 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid; Pirinixic acid

CAS Number: 50892-23-4
Empirical Formula (Hill Notation): C14H14ClN3O2S
Molecular Weight: 323.80
MDL Number: MFCD00191335
Linear Formula: C14H14ClN3O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C7081-10MG 10 mg
 $62.00
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45-C7081-50MG 50 mg
 $199.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C7081-50MG

 

form powder
InChI 1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)
InChI key SZRPDCCEHVWOJX-UHFFFAOYSA-N
Quality Level 100 
SMILES string CC1=C(C)C=CC=C1NC2=NC(SCC(O)=O)=NC(Cl)=C2
Application: WY-14643 has been used:
• as a positive control for transfection and luciferase assay
• to stimulate bone marrow–derived macrophages (BMDM) for autophagic flux analysis
• to analyze the regulation of fatty acid metabolism-immune nexus (FAMIN) expression in cell culture
Biochem/physiol Actions: Selective PPARα agonist.
Features and Benefits: This compound is featured on the Nuclear Receptors (Non-Steroids)  and Nuclear Receptors (PPARs)  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: WY-14643 prevents lipopolysaccharide (LPS)-induced inflammation in synovial fibroblasts. It protects cortical neurons from pro-inflammatory mediator-induced cell injuries. WY-14643 has inhibitory effects on pro-inflammatory responses in microglia. It improves oxido-nitrosative stress in disease models and reduces the generation of reactive oxygen species (ROS), nitric oxide (NO) and lipid peroxidation end-products in the brain.
Packaging: 10 mg in glass insert
Packaging: 50 mg in glass bottle
UNSPSC 12352200

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