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CI-1033

SIGMA/C7249 - ≥98% (HPLC)

Synonym: Canertinib dihydrochloride; N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride; N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride; PD183805

CAS Number: 289499-45-2
Empirical Formula (Hill Notation): C24H25ClFN5O3· 2HCl
Molecular Weight: 558.86
MDL Number: MFCD09954112
Linear Formula: C24H25ClFN5O3· 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C7249-5MG 5 mg
 $95.60
1/EA		 Add To Favorites
45-C7249-25MG 25 mg
 $387.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
form solid
InChI 1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16;;/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29);2*1H
InChI key JZZFDCXSFTVOJY-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.Cl.Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
solubility DMSO: >10 mg/mL
  H2O: >10 mg/mL
storage temp. −20°C
Biochem/physiol Actions: CI-1033 is a potent, irreversible ATP binding site–directed pan-ErbB tyrosine kinase inhibitor with IC50 in the low nanomolar range for EGFR, HER2, and ErbB-4.
Biochem/physiol Actions: CI-1033 is a potent, irreversible pan-erbB tyrosine kinase inhibitor.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the EGFR  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H315 - H319 - H335
Precautionary statements P261 - P305 + P351 + P338
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 51111800

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