Clomipramine hydrochloride
SIGMA/C7291 - ≥98% (HPLC), powder
Synonym: 3-
CAS Number: 17321-77-6
Empirical Formula (Hill Notation): C19H23ClN2 · HCl
Molecular Weight: 351.31
EC Number: 241-344-3
MDL Number: MFCD00069234
Linear Formula: C19H23ClN2 · HCl
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C7291-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C7291-5G
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C19H23ClN2.ClH/c1-21(2 |
| InChI key | WIMWMKZEIBHDTH-UHFFFAOYSA |
| originator | Novartis |
| Quality Level | 200  |
| SMILES string | Cl.CN(C)CCCN1c2ccccc2CCc3 |
| solubility | 0.1 M HCl: soluble |
| H2O: 25 mg/mL |
| Application: | Clomipramine hydrochloride has been used to manipulate serotonin (5-HT) mechanisms. It has also been used to study its role on bone mass. |
| Application: | Clomipramine hydrochloride has been used: • to study its effect on human serum albumin using UV-visible, fluorescence and circular dichroism (CD) techniques • to block itchy E3 ubiquitin protein ligase (ITCH) ubiquitin transthiolation • as a serotonin reuptake inhibitor • as a homologous to E6AP C terminus (HECT) E3 ligase inhibitor |
| Biochem/physiol Actions: | Clomipramine hydrochloride (CLP) is a amphiphilic drug, with two benzene rings in its structure. It exhibits anti-depressant property by restoring the equilibrium of certain natural materials in the human being. CLP acts as a potential therapeutic for obsessive compulsive disorder. |
| Biochem/physiol Actions: | Tricyclic antidepressant; inhibits serotonin and norepinephrine transporters. |
| Features and Benefits: | This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Novartis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: | Clomipramine hydrochloride is an antiobsessional drug. It has anticholinergic activity in vitro and in vivo. Clomipramine is used to treat obsessive compulsive disorder and panic disorder. |
| Packaging: | 1, 5 g in poly bottle |
| Symbol |    GHS07,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H302 - H336 - H370 - H410 |
| Precautionary statements | P260 - P264 - P270 - P273 - P301 + P312 - P308 + P311 |
| Hazard Codes | Xn,N |
| Risk Statements | 63-22-50/53 |
| Safety Statements | 13-20/21-22-24/25-26-28-36/37/39-38-62 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Purity | ≥98% (HPLC) |
| UNSPSC | 12352116 |