Cyclic adenosine diphosphate-ribose

SIGMA/C7344 - ≥90% (HPLC), lyophilized powder

Synonym: ADP-cyclo[N¹:1′′]-ribose; Cyclic ADPR; cADP-ribose; cADPR

CAS Number: 119340-53-3
Empirical Formula (Hill Notation): C₁₅H₂₁N₅O₁₃P₂
Molecular Weight: 541.30
MDL Number: MFCD00214262
Linear Formula: C₁₅H₂₁N₅O₁₃P₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-C7344-.5MG	0.5 mg	$356.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (HPLC)
biological source	(Ovotestis from sea hare)
form	lyophilized powder
InChI	1S/C15H21N5O13P2/c16-12-7-13-18-4-19(12)14-10(23)8(21)5(31-14)1-29-34(25,26)33-35(27,28)30-2-6-9(22)11(24)15(32-6)20(13)3-17-7/h3-6,8-11,14-16,21-24H,1-2H2,(H,25,26)(H,27,28)/t5-,6-,8-,9-,10-,11-,14-,15-/m1/s1
InChI key	BQOHYSXSASDCEA-KEOHHSTQSA-N
Quality Level	200
SMILES string	O[C@H]1[C@@H](O)[C@H]2O[C@@H]1COP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)[n@H]4cnc5C(=N)[N@@H]2C=Nc45
solubility	water: 5 mg/mL, clear, colorless
storage temp.	−20°C

Application:	Cyclic adenosine diphosphate-ribose (cADPR) is an intracellular second messenger that mobilizes intracellular Ca²⁺ release from the sarcoplasmic reticulum through ryanodine receptors. CADPR is also a second messenger for glucose-induced insulin release from endocrine pancreas and for abscisic acid-induced calcium release in plants.
Application:	Cyclic adenosine diphosphate-ribose has been used to stimulate astrocytes to activate CD38 signaling. It has also been used as a supplement in buffered peptone water to recover S. enteritidis.
Biochem/physiol Actions:	Mobilizes intracellular Ca²⁺; regulates Ca²⁺-induced Ca²⁺ release specifically blocked by ryanodine; second messenger for glucose-induced insulin release from the endocrine pancreas and for abscisic acid-induced calcium release in plants.
Packaging:	0.5 mg in glass bottle
Packaging:	Package size based on nucleotide content.
Physical form:	Lyophilized powder

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

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