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CK-636

SIGMA/C7374 - ≥98% (HPLC)

Synonym: CK-0944636; N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide

CAS Number: 442632-72-6
Empirical Formula (Hill Notation): C16H16N2OS
Molecular Weight: 284.38
MDL Number: MFCD03036245
Linear Formula: C16H16N2OS
Product Type: Custom product
Catalog Number PKG Qty. Price Quantity
45-C7374-5MG 5 mg
 $92.70
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assay ≥98% (HPLC)
color peach to light pink
form powder
InChI 1S/C16H16N2OS/c1-11-12(13-5-2-3-6-14(13)18-11)8-9-17-16(19)15-7-4-10-20-15/h2-7,10,18H,8-9H2,1H3,(H,17,19)
InChI key ACAKNPKRLPMONU-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cc1[nH]c2ccccc2c1CCNC(=O)c3cccs3
solubility DMSO: ≥20 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes.
Biochem/physiol Actions: CK-636 inhibits the activity of actin-related protein (Arp)2/3 complex; binds between Arp2 and Arp3, blocks movement of Arp2 and Arp3 into active conformations, inhibits ability to nucleate actin filaments.
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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