Concanavalin A from Canavalia ensiformis (Jack bean)

SIGMA/C7555 - agarose conjugate, Type VI, saline suspension

Synonym: ConA

Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-C7555-5ML	5 mL	$186.00 1/EA		Add To Favorites
45-C7555-25ML	25 mL	$632.00 1/EA		Add To Favorites
45-C7555-100ML	100 mL	$1750.00 1/EA		Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

biological source	Canavalia ensiformis
conjugate	agarose conjugate
extent of labeling	≥15 mg concanavalin A protein per mL
form	saline suspension
matrix	cross-linked 4% beaded agarose
matrix activation	cyanogen bromide
matrix attachment	amino
matrix spacer	1 atom
Quality Level	200
storage temp.	2-8°C
type	Type VI

Analysis Note:	Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, containing Ca²⁺ and Mn²⁺ of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C.
Application:	Concanavalin A (Con A) has been used for enzyme immobilization.
Application:	Used for the purification of glycoproteins containing mannose
Biochem/physiol Actions:	Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca²⁺ and Mn²⁺ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.
Biochem/physiol Actions:	Concanavalin A (Con A) is a T cell mitogen that can activate the lymphocytes. Con A can induce tumor cell death through autophagy.
General description:	Concanavalin A (Con A), isolated from Jack beans (Canavalia ensiformis), is a mannose or glucose specific-binding lectin. The lectin is a tetramer and each subunit possesses a saccharide-binding site. Con A can be isolated by affinity chromatography with dextrans.
Physical form:	Suspension in 1.0 M NaCl + 0.1 M potassium phosphate, pH 6.0, with 1 mM CaCl₂, 1 mM MgCl₂ and 1 mM MnCl₂ containing preservative

RIDADR	NONH for all modes of transport
WGK Germany	WGK 1

Storage Temp.	2-8°C
UNSPSC	12161501

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