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Combretastatin A4

SIGMA/C7744 - ≥98% (HPLC), powder

Synonym: 1-(3,4,5-Trimethoxyphenyl)-2-(3′-hydroxy-4′-methoxyphenyl) ethane 3,4,5-trimethoxy-3′-hydroxy-4′-methoxystilbene; 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol; CA4

CAS Number: 117048-59-6
Empirical Formula (Hill Notation): C18H20O5
Molecular Weight: 316.35
MDL Number: MFCD03453309
Linear Formula: C18H20O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C7744-5MG 5 mg
 $120.00
1/EA		 Add To Favorites
45-C7744-25MG 25 mg
 $499.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color off-white
form powder
InChI 1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
InChI key HVXBOLULGPECHP-WAYWQWQTSA-N
Quality Level 100 
SMILES string COc1ccc(C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
solubility DMSO: >10 mg/mL
storage temp. −20°C
Application: Combretastatin A4 has been used:
• as an anti-tubulin agent to determine the effects of isocitrate dehydrogenases (IDH1 and IDH2) proteins in G2/M phase
•  to evaluate the anti-proliferative and pro-apoptotic properties of biphenyl CA4 derivatives in both 2D and 3D cancerous and non-cancerous cell models
•  as a microtubule inhibitor to study its effects on motility of Ascaris suum L3 larvae
Biochem/physiol Actions: Combretastatin A4 is a potent microtubule targeting agent (MTA).
Biochem/physiol Actions: Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis.
Biochem/physiol Actions: Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest, and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A4 is a natural stilbenoid phenol.
General description: Combretastatin A4 belong to the class of colchicinoids compounds.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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