Collagen from bovine nasal septum
SIGMA/C7806 - Bornstein and Traub Type II, powder
Synonym: Collagen from bovine
CAS Number: 9007-34-5
EC Number: 232-697-4
MDL Number: MFCD00130825
Product Type: Chemical
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| biological source | bovine nasal septum |
| form | powder |
| Quality Level | 200  |
| solubility | aqueous acid: soluble |
| storage temp. | 2-8°C |
| technique(s) | ELISA: suitable |
| UniProt accession no. | P02459  |
| Application: | Collagen from bovine nasal septum has been used to coat the plates to estimate the levels of serum anti-cII IgG by enzyme-linked immunosorbent assay (ELISA). It has also been used as a component in the emulsified agent to induce arthritis in rats. |
| Application: | Collagen-type II has been investigated for its importance in haemostasis. Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type 2. Collagen-type 2 has also been used as a model for arthritis in animals, where FR140423, a selective cyclooxygenase (COX)-2 inhibitor, has shown an anti-inflammatory effect without gastric lesions that may occur with treatment via indomethacin. Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. However, under conditions leading to formation of reactive oxygen species, the subjects develop tolerance for auto-antibodies. This is an unusual situation of ROS having a favorable effect. |
| Biochem/physiol Actions: | Collagen is the structural constituent of the dermis, which provides strength and support to the human skin. Variations in collagen participates in the aging process. |
| General description: | Collagen is a fibrous protein, found in connective tissues, hard tissues, bone, dentin, cementum and also the mineralizing cartilage of the epiphyseal growth plate. |
| General description: | Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types. |
| Packaging: | 10 mg in poly bottle |
| Packaging: | 5 mg in glass bottle |
| Preparation Note: | An acid soluble collagen soluble in dilute acetic acid at pH 3.0 (5 mg/ml), yielding an opalescent, colorless solution. |
| Preparation Note: | Collagen Type II is a triple helix composed of three α1(II) strands. |
| Preparation Note: | Prepared by a modification of the pepsin extraction procedure of Niyibizi, et al., J. Biol. Chem., 259, 14170 (1984). |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352202 |