Curdlan from Alcaligenes faecalis
SIGMA/C7821
Synonym: β-1,3-Glucan hydrate
CAS Number: 54724-00-4
MDL Number: MFCD00212920
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C7821-5G
| form | solid |
| Quality Level | 200  |
| storage temp. | 2-8°C |
| Application: | Curdlan from Alcaligenes faecalis has been used: • for the stimulation of carp macrophages for regulation of differentially expressed genes • to stimulate human intestinal epithelial cells for cytokine secretion • to study its effect on transcriptional responses of inflammation/respiratory burst-associated genes in mouse alveolar macrophages by customized reverse transcription (RT)-PCR based arrays • as a substrate in β-1,3–1,4-Glucanase activity assay |
| Biochem/physiol Actions: | Curdlan is a (1,3)-β-glucan. It is a pathogen-associated molecular-pattern (PAMP) recognized by the receptor dectin-1. Activation of dectin-1, together with TLR2/TLR6, promotes signaling resulting in the production of pro-inflammatory cytokines, thus inducing inflammation. |
| Biochem/physiol Actions: | Curdlan is used as a food additive in the food industry. It improves the elasticity and reduces the embrittling tendency of hydroxyapatite/chitosan scaffold, which aids in bone regeneration. |
| General description: | Curdlan is an insoluble natural polymer with linear structure mainly produced by Alcaligenes faecalis. It is a dietary fiber with gelatin properties. |
| Packaging: | 5 g in glass bottle |
| Preparation Note: | For gelation at 70 °C, the concentration of the sodium hydroxide should be 0.01 M. |
| Preparation Note: | This product is tested for solubility in 0.1N sodium hydroxide at a concentration of 9.8 - 10.2 mg/mL. Heating and/or sonication are typically required for solubilization. This product is not sterile. For use in cell culture, stock solutions should be filter sterilized prior to use. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |