Clonidine hydrochloride
SIGMA/C7897 - solid
Synonym: 2-
CAS Number: 4205-91-8
Empirical Formula (Hill Notation): C9H9Cl2N3 · HCl
Molecular Weight: 266.55
EC Number: 224-121-5
MDL Number: MFCD00036705
Linear Formula: C9H9Cl2N3 · HCl
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C7897-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C7897-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C7897-250MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C7897-5G
| color | white |
| form | solid |
| InChI | 1S/C9H9Cl2N3.ClH/c10-6-2- |
| InChI key | ZNIFSRGNXRYGHF-UHFFFAOYSA |
| originator | Boehringer Ingelheim |
| Quality Level | 100  |
| SMILES string | Cl[H].Clc1cccc(Cl)c1NC2=N |
| solubility | H2O: soluble |
| methanol: soluble | |
| storage temp. | 2-8°C |
| Application: | Clonidine hydrochloride has been used as an adrenergic receptor (ADRA2A) agonist: • in ex vivo leptin release assay • to study its effects on pain hypersensitivity in 6-OHDA lesioned rats • to study its influence on the sleep of larval zebrafish • to manipulate noradrenaline and examine its influence on behavioral flexibility and motivation |
| Application: | Clonidine hydrochloride has been used: • to reduce central noradrenaline levels • to inhibit allyl isothiocyanate (AITC) sensitized thermal aversion • to attenuate thermal and mechanical pain hypersensitivity in rats • as a positive control for pertussis toxin (PTX) |
| Biochem/physiol Actions: | α2-adrenoceptor agonist; I1 imidazoline binding site ligand. |
| Biochem/physiol Actions: | Clonidine hydrochloride is used for management of hypertension in pregnant women. In addition, it also acts as a therapeutic for neonatal abstinence syndrome. Clonidine hydrochloride binds to central α-adrenergic receptors and reduces the efferent sympathetic neuronal vasoconstrictor tone to the heart, kidneys and peripheral vasculature leading to vasodilatation and reduction in the blood pressure. |
| Features and Benefits: | This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Boehringer Ingelheim . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: | Clonidine hydrochloride has antihypertensive analgesic and antidiarrheal properties. It lowers short-circuit current, blocks anion secretion, improves mucosal absorption of fluids and electrolytes in vitro. Clonidine is used to treat attention deficit and hyperactivity disorders (ADHD), menopausal flushing, drug withdrawal and Tourette′s syndrome. |
| Packaging: | 1, 5 g in glass bottle |
| Packaging: | 100, 250 mg in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 - H330 |
| Precautionary statements | P301 + P310 + P330 - P304 + P340 + P310 |
| Hazard Codes | T+ |
| Risk Statements | 25-26 |
| Safety Statements | 22-26-28-36/37/39-45 |
| RIDADR | UN 2811PIH 6.1 / PGI |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |