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Cefotaxime sodium salt

SIGMA/C7912 - potency: 916-964 μg per mg

Synonym: Cefotaxime; Cefotaxim sodium salt

CAS Number: 64485-93-4
Empirical Formula (Hill Notation): C16H16N5NaO7S2
Molecular Weight: 477.45
EC Number: 264-915-9
MDL Number: MFCD00079073
Linear Formula: C16H16N5NaO7S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C7912-1G 1 g
 $250.00
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45-C7912-5G 5 g
 $857.00
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antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
form powder
InChI 1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
InChI key AZZMGZXNTDTSME-JUZDKLSSSA-M
mode of action cell wall synthesis | interferes
potency 916-964 μg per mg
Quality Level 200 
SMILES string [Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)c3csc(N)n3)C([O-])=O
solubility H2O: 50 mg/mL
storage temp. 2-8°C
Application: Cefotaxim has been used to find new residues involved in cefotaxime hydrolysis in CTX-M β-lactamases, to study antibiotic-susceptible and -resistant Streptococcus pneumoniae infections, and to study pneumococcal pneumonia and the pharmokinetics of various treatments. It may be used to study the effects of binding and inhibition of penicillin binding protein 2 (PBP2) on bacterial mucopeptide synthesis.
Biochem/physiol Actions: Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
Biochem/physiol Actions: Mode of Action: Inhibits bacterial cell wall synthesis.
General description: Chemical structure: ß-lactam
Other Notes: Broad spectrum third generation cephalosporin antibiotic.
Other Notes: Keep container tightly closed in a dry and well-ventilated place.
Symbol GHS08  GHS08
Signal word Danger
Hazard statements H317 - H334
Precautionary statements P261 - P280 - P342 + P311
Hazard Codes Xn
Risk Statements 42/43
Safety Statements 22-36/37
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. 2-8°C
UNSPSC 51284136

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