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Cilostamide

SIGMA/C7971 - phosphodiesterase inhibitor

Synonym: 6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one; OPC 3689

CAS Number: 68550-75-4
Empirical Formula (Hill Notation): C20H26N2O3
Molecular Weight: 342.43
MDL Number: MFCD00673958
Linear Formula: C20H26N2O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C7971-5MG 5 mg
 $499.00
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assay ≥97% (HPLC)
form powder
InChI 1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
InChI key UIAYVIIHMORPSJ-UHFFFAOYSA-N
Quality Level 100 
SMILES string CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2
solubility DMSO: 20 mg/mL, clear, colorless to faintly yellow
Biochem/physiol Actions: PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures. Cilostamide is known to delay meiotic progression.
Biochem/physiol Actions: Selective cGMP-inhibited phosphodiesterase inhibitor (PDE3); IC50 = 70 ± 9 nM.
Biochem/physiol Actions: Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC50 = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
UNSPSC 12352202

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