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CH-223191

SIGMA/C8124

Synonym: 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phen yl-1H-pyrazole-5-carboxamide; 2-Methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide

CAS Number: 301326-22-7
Empirical Formula (Hill Notation): C19H19N5O
Molecular Weight: 333.39
MDL Number: MFCD00377884
Linear Formula: C19H19N5O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C8124-5MG 5 mg
 $121.00
1/EA		 Add To Favorites
45-C8124-25MG 25 mg
 $488.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color orange-brown
form powder
InChI 1S/C19H19N5O/c1-13-6-4-5-7-17(13)23-22-15-8-9-16(14(2)12-15)21-19(25)18-10-11-20-24(18)3/h4-12H,1-3H3,(H,21,25)/b23-22+
InChI key LKTNEXPODAWWFM-GHVJWSGMSA-N
Quality Level 100 
SMILES string Cc1cc(ccc1NC(=O)c2ccnn2C)N=Nc3ccccc3C
solubility DMSO: ≥20 mg/mL
storage temp. 2-8°C
Application: CH-223191 has been used as aryl hydrocarbon receptor (AHR) antagonist in HepaRG cells, TH17-IL-10+ cells and organoids.
Biochem/physiol Actions: CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist.
Biochem/physiol Actions: CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. It inhibited TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibited TCDD-induced luciferase activity with an IC50 of 30nM. Unlike some other AhR antagonists which display agonist activity at high concentrations, CH-223191 did not stimulate AhR-dependent transcription even at 100 micromolar. It is also specific for AhR, displaying no affinity for the estrogen receptor, as some other antagonists do.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Nuclear Receptors (Non-Steroids)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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