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Chlorpromazine hydrochloride

SIGMA/C8138 - ≥98% (TLC)

Synonym: 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride; CPZ; Largactil

CAS Number: 69-09-0
Empirical Formula (Hill Notation): C17H19ClN2S · HCl
Molecular Weight: 355.33
EC Number: 200-701-3
MDL Number: MFCD00012654
Linear Formula: C17H19ClN2S · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C8138-5G 5 g
 $120.00
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45-C8138-25G 25 g
 $506.00
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45-C8138-100G 100 g
 $1120.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C8138-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C8138-25G

 

assay ≥98% (TLC)
form powder
InChI 1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
InChI key FBSMERQALIEGJT-UHFFFAOYSA-N
mp 194-196 °C
originator GlaxoSmithKline
Quality Level 200 
SMILES string Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13
solubility water: 50 mg/mL
Application: Chlorpromazine hydrochloride has been used:
• as an antagonists for calmodulin kinase
• as a medium supplement to test its cytotoxic effects in human lung microvascular endothelial cells (HMVEC-L)
• as an inhibitor of clathrin-mediated endocytosis in RAW 264.7 cells
Application: Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.
Biochem/physiol Actions: Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.
Biochem/physiol Actions: Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25, 100 g in glass bottle
Purity ≥98% (TLC)
mp 194-196 °C
UNSPSC 12352200

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