Complement C4 from human serum
SIGMA/C8195 - ≥300,000 C4H50 units/mg protein
CAS Number: 80295-48-3
MDL Number: MFCD00130838
Product Type: Chemical
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| biological source | human serum |
| form | solution |
| Quality Level | 200  |
| shipped in | dry ice |
| specific activity | ≥300,000 C4H50 units/mg protein |
| storage temp. | −70°C |
| technique(s) | activity assay: suitable |
| UniProt accession no. | P0C0L4  |
| Application: | Complement C4 from human serum has been used in mannose binding lectin (MBL) complex assay of serum samples and in MBL-associated serine proteases based C4 activation assay of plasma samples. |
| Biochem/physiol Actions: | Complement C4 serves a primary role in the classical and lectin pathways of the complement system and provides protection against bacterial pathogens. C4 polymorphisms have been used in research to study their associations with the hemolytic and antibacterial ability of the classical pathway. |
| Biochem/physiol Actions: | There are strong indications that complement C4 deficiency is correlated with induction of systemic lupus erythematosus (SLE) and other autoimmune diseases. |
| Biochem/physiol Actions: | Variation in the copy number of the complement C4 gene alters the complement c4A and c4B levels in age-related macular degeneration (AMD) and increases risk of developing schizophrenia. |
| Disclaimer: | RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization. |
| General description: | Complement C4 is mapped to human chromosome 6p21.33. It exists in two isoforms as c4A and c4B. C4 is a 200 kDa protein belonging to α2 macroglobulin (α2M) family. It undergoes posttranslational modification like sulfation and glycosylation and finally proteolysis to become a mature protein. |
| Other Notes: | View more information on the complement pathway at www.sigma-aldrich.com/enz |
| Physical form: | Supplied as a solution in PBS, pH 7.2 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥300,000 C4H50 units/mg protein |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |