Cardamonin
SIGMA/C8249 - ≥98% (HPLC)
Synonym: (2E)
CAS Number: 19309-14-9
Empirical Formula (Hill Notation): C16H14O4
Molecular Weight: 270.28
MDL Number: MFCD00238554
Linear Formula: C16H14O4
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C8249-25MG.
| assay | ≥98% (HPLC) |
| color | light yellow to dark brown |
| form | powder |
| InChI | 1S/C16H14O4/c1-20-15-10-1 |
| InChI key | NYSZJNUIVUBQMM-BQYQJAHWSA |
| Quality Level | 100  |
| SMILES string | O=C(/C=C/C1=CC=CC=C1)C2=C |
| solubility | DMSO: ≥20 mg/mL |
| storage temp. | room temp |
| Application: | Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos. |
| Application: | Cardamonin has been used as a standard in high performance liquid chromatography (HPLC) to analyze phenolic compounds in acacia honey samples. |
| Biochem/physiol Actions: | Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). |
| Biochem/physiol Actions: | Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). Cardamonin inhibits pigmentation in melanocytes through suppression of Wnt/b-catenin signaling pathway. Cardamonin suppressed Wnt/b-catenin signaling by a mechanism involving proteasome-mediated degradation of b-catenin (GSK-3b-independent pathway). Research has shown that Cardamonin possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS09 |
| Signal word | Warning |
| Hazard statements | H400 |
| Precautionary statements | P273 |
| Hazard Codes | N |
| Risk Statements | 50/53 |
| Safety Statements | 61 |
| RIDADR | UN 3077 9 / PGIII |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |