Cardamonin
SIGMA/C8249 - ≥98% (HPLC)
Synonym: (2E)
CAS Number: 19309-14-9
Empirical Formula (Hill Notation): C16H14O4
Molecular Weight: 270.28
MDL Number: MFCD00238554
Linear Formula: C16H14O4
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | light yellow to dark brown |
| form | powder |
| InChI | 1S/C16H14O4/c1-20-15-10-1 |
| InChI key | NYSZJNUIVUBQMM-BQYQJAHWSA |
| Quality Level | 100  |
| SMILES string | O=C(/C=C/C1=CC=CC=C1)C2=C |
| solubility | DMSO: ≥20 mg/mL |
| storage temp. | room temp |
| Application: | Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos. |
| Application: | Cardamonin has been used as a standard in high performance liquid chromatography (HPLC) to analyze phenolic compounds in acacia honey samples. |
| Biochem/physiol Actions: | Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). |
| Biochem/physiol Actions: | Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). Cardamonin inhibits pigmentation in melanocytes through suppression of Wnt/b-catenin signaling pathway. Cardamonin suppressed Wnt/b-catenin signaling by a mechanism involving proteasome-mediated degradation of b-catenin (GSK-3b-independent pathway). Research has shown that Cardamonin possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS09 |
| Signal word | Warning |
| Hazard statements | H400 |
| Precautionary statements | P273 |
| Hazard Codes | N |
| Risk Statements | 50/53 |
| Safety Statements | 61 |
| RIDADR | UN 3077 9 / PGIII |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |