Synonym: 7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione
CAS Number: 22316-47-8
Empirical Formula (Hill Notation): C16H13ClN2O2
Molecular Weight: 300.74
EC Number: 244-908-7
MDL Number: MFCD00079069
Linear Formula: C16H13ClN2O2
Product Type: Chemical
| drug control |
USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet |
| form |
powder |
| InChI |
1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3 |
| InChI key |
CXOXHMZGEKVPMT-UHFFFAOYSA-N |
| Quality Level |
200  |
| SMILES string |
CN1C(=O)CC(=O)N(c2ccccc2)c3cc(Cl)ccc13 |
| Application: |
Clobazam has been used as a benzodiazepine to test its effect on the activation of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR). |
| Biochem/physiol Actions: |
Anxiolytic; ligand for the GABAA receptor benzodiazepine modulatory site. |
| Biochem/physiol Actions: |
Clobazam interacts at α and γ2 subunits junction of the GABAA receptor. It is less sedative and elicits anxiolytic and anticonvulsant effects. Clobazam is more selective on the α2 subunit of the GABAA receptor than the α1 subunit. It is an antiseizure drug and is associated with antiepileptic activity. Clobazam is useful in treating chronic epileptic encephalopathy disorder, Lennox‐Gastaut syndrome. It is employed in epilepsy and seizure prevention adjunctive therapy. |
| General description: |
Clobazam is a benzodiazepine, comprising of B ring nitrogen placed in positions 1 and 5 contrary to 1,4-benzodiazepines. It is a ligand for γ-aminobutyric acid type A (GABAA) receptor and is metabolized by cytochrome P450 in the liver. |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
