COG 133 trifluoroacetate salt

SIGMA/C8624 - ≥95% (HPLC)

Synonym: Ac- LRVRLASHLRKLRKRLL-NH2; Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu- Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2; COG133; N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-Leucinamide; apoE(133-149)

CAS Number: 514200-66-9 (free base)
Empirical Formula (Hill Notation): C₉₇H₁₈₁N₃₇O₁₉ · xC₂HF₃O₂
Molecular Weight: 2169.71 (free base basis)
MDL Number: MFCD18432706
Linear Formula: C₉₇H₁₈₁N₃₇O₁₉ · xC₂HF₃O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C8624-1MG	1 mg	$266.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
color	white
form	lyophilized
InChI	1S/C97H181N37O20.C2HF3O2/c1-50(2)40-67(119-58(16)136)85(146)125-66(32-25-39-116-97(108)109)83(144)134-75(56(13)14)91(152)126-65(31-24-38-115-96(106)107)82(143)127-68(41-51(3)4)84(145)118-57(15)76(137)133-74(48-135)90(151)131-72(46-59-47-111-49-117-59)89(150)130-70(43-53(7)8)87(148)124-63(29-22-36-113-94(102)103)79(140)121-61(27-18-20-34-99)80(141)128-69(42-52(5)6)86(147)123-62(28-21-35-112-93(100)101)78(139)120-60(26-17-19-33-98)77(138)122-64(30-23-37-114-95(104)105)81(142)129-71(44-54(9)10)88(149)132-73(45-55(11)12)92(153)154-110;3-2(4,5)1(6)7/h47,49-57,60-75,135H,17-46,48,98-99,110H2,1-16H3,(H,111,117)(H,118,145)(H,119,136)(H,120,139)(H,121,140)(H,122,138)(H,123,147)(H,124,148)(H,125,146)(H,126,152)(H,127,143)(H,128,141)(H,129,142)(H,130,150)(H,131,151)(H,132,149)(H,133,137)(H,134,144)(H4,100,101,112)(H4,102,103,113)(H4,104,105,114)(H4,106,107,115)(H4,108,109,116);(H,6,7)/t57-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-;/m0./s1
InChI key	SIAUOBGYBRMVPH-BGJGLIJFSA-N
Quality Level	100
SMILES string	OC(=O)C(F)(F)F.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)ON
solubility	H₂O: >1 mg/mL
storage temp.	−20°C

Biochem/physiol Actions:	COG 133 is an apoE protein fragment that blocks neurodegeneration and restores cognitive functions.
Biochem/physiol Actions:	COG 1333 or apoE(133-149) is a fragment of Apolipoprotein E (APOE) that mimics the functional anti-inflammatory and neuroprotective effects of the intact apoE protein. It was suggested that neuroprotective functions of the mimetic results from binding to the low-density lipoprotein receptor-related protein (LRP) or LDL receptors, and such binding results in inhibition of the N-methyl-D-aspartate (NMDA) receptor.
Packaging:	1 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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