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4-Chloro-L-phenylalanine

SIGMA/C8655

Synonym: L-PCPA

CAS Number: 14173-39-8
Empirical Formula (Hill Notation): C9H10ClNO2
Molecular Weight: 199.63
EC Number: 238-023-5
MDL Number: MFCD00063065
Linear Formula: ClC6H4CH2CH(NH2)CO2H
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C8655-250MG 250 mg
 $365.00
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45-C8655-1G 1 g
 $680.00
1/EA		 Add To Favorites

 

form powder
InChI 1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m0/s1
InChI key NIGWMJHCCYYCSF-QMMMGPOBSA-N
mp 263 °C (dec.) (lit.)
Quality Level 200 
SMILES string N[C@@H](Cc1ccc(Cl)cc1)C(O)=O
storage temp. −20°C
Application: 4-Chloro-L-phenylalanine (L-PCPA) has been used:
• to block serotonin synthesis by inhibiting tryptophan hydroxylase (TPH)
• to study its behavioral and electrographic effects on epileptic senegalese baboon (Papio papio)
• as a substrate for Chromobacterium violaceum phenylalanine hydroxylase
• to incubate sea urchin embryos for immunohistochemistry
Biochem/physiol Actions: 4-Chloro-L-phenylalanine (L-PCPA) inhibits the synthesis of 5-hydroxytryptamine (5-HT). 4-Chloro-DL-phenylalanine (PCPA) depletes the serotonin levels in the brain by its inhibitory effect on tryptophan hydroxylase (Tph). Studies support the protective effects of PCPA against monocrotaline-induced pulmonary vascular remodeling as well as in lung inflammation.
Biochem/physiol Actions: Tryptophan hydroxylase inhibitor.
Packaging: 1 g in glass bottle
Packaging: 250 mg in glass bottle
Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
Hazard Codes T
Risk Statements 25-43
Safety Statements 36/37-45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
mp 263 °C (dec.) (lit.)
Storage Temp. −20°C
UNSPSC 12352209

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