Cathepsin D from human liver
SIGMA/C8696 - lyophilized powder, ≥250 units/mg protein (E1%/280 )
CAS Number: 9025-26-7
MDL Number: MFCD00130749
Product Type: Chemical
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| color | white |
| form | lyophilized powder |
| mol wt | ~45 kDa |
| Quality Level | 200  |
| specific activity | ≥250 units/mg protein (E |
| storage temp. | −20°C |
| UniProt accession no. | P07339  |
| Application: | Cathepsin D from human liver has been used: • in β-secretase activity assay • for enzymatic degradation of amyloid β 1-42 • in microinjection of human foreskin fibroblasts |
| Biochem/physiol Actions: | Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer’s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced. |
| Biochem/physiol Actions: | Endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer’s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. |
| General description: | Cathepsin D is an aspartic protease, which is located in lysosomes. It is involved in protein catabolism and maintains hormone and antigen processing. Cathepsin D is implicated in neoplasia and neurodegenerative changes. It regulates lysosomal proteolysis and endogenous fibrinolysis. |
| Other Notes: | Contains α, β and γ isoenzymes as observed by isoelectric-focusing. |
| Other Notes: | One unit will produce an increase in A280 of 1.0 in 30 min at pH 3.3 at 37 °C measured as TCA-soluble products using acid-denatured hemoglobin as substrate (1 cm light path). |
| Physical form: | Powder containing sodium phosphate buffer salt. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥250 units/mg protein (E |
| Storage Temp. | −20°C |
| Enzyme Commission (EC) Number | 3.4.23.5 ( BRENDA | IUBMB ) |
| UNSPSC | 12352204 |