Cyclin-Dependent Kinase 5 human
SIGMA/C8739 - recombinant, expressed in E. coli BL21, 50-100 units/μg protein
MDL Number: MFCD06201997
Product Type: Chemical
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| form | solution |
| packaging | vial of 300 units |
| Quality Level | 200  |
| recombinant | expressed in E. coli BL21 |
| shipped in | dry ice |
| specific activity | 50-100 units/μg protein |
| storage temp. | −70°C |
| Application: | Human cyclin-dependent kinase 5 has been used in a study to determine its 3’ untranslated region subunit 1 contains regulatory elements that affect transcript stability. |
| Biochem/physiol Actions: | CDK5 is highly expressed in the nervous system where it phosphorylates a multitude of substrates. CDK5 plays an important role in many processes such as: apoptosis, phototransduction, dopamine and glutamate signalling, neurite outgrowth, neurone migration, induction of acetylcholine receptors, golgi membrane traffic and insulin exocytosis. It has also been implicated in the pathogenesis of amyotrophic lateral sclerosis . It is activated by p35 and p39, and their proteolytic cleavage products, p25 and p29. |
| Other Notes: | One unit will phosphorylate 1.0 picomole of the peptide substrate histone H19-18 per minute at 30 °C at pH 7.4. |
| Physical form: | Supplied as a solution in PBS pH 7.4, 1 mM EDTA, 1mM DTT and 1 mg/ml BSA |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: 50-100 units/μg protein |
| Storage Temp. | −70°C |
| UNSPSC | 12352204 |