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CHIC-35

SIGMA/C8742 - ≥97% (chiral, HPLC)

Synonym: (6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide; Compound (S)-35

CAS Number: 848193-72-6
Empirical Formula (Hill Notation): C14H15ClN2O
Molecular Weight: 262.73
MDL Number: MFCD11045286
Linear Formula: C14H15ClN2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C8742-1MG 1 mg
 $193.00
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45-C8742-5MG 5 mg
 $569.00
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assay ≥97% (chiral, HPLC)
form solid
InChI 1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1
InChI key ABIVOOWWGYJNLV-JTQLQIEISA-N
Quality Level 100 
SMILES string ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1
solubility DMSO: >10 mg/mL
  H2O: <2 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1.
Biochem/physiol Actions: CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 1, 5 mg in glass bottle
Hazard Codes Xn
Risk Statements 36/37/38
Safety Statements 26
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Purity ≥97% (chiral, HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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