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CGP-37157

SIGMA/C8874 - ≥98% (HPLC), powder

Synonym: 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one

CAS Number: 75450-34-9
Empirical Formula (Hill Notation): C15H11Cl2NOS
Molecular Weight: 324.22
MDL Number: MFCD09055422
Linear Formula: C15H11Cl2NOS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C8874-5MG 5 mg
 $171.00
1/EA		 Add To Favorites
45-C8874-25MG 25 mg
 $648.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
form powder
InChI 1S/C15H11Cl2NOS/c16-9-5-6-13-11(7-9)15(20-8-14(19)18-13)10-3-1-2-4-12(10)17/h1-7,15H,8H2,(H,18,19)
InChI key KQEPIRKXSUIUTH-UHFFFAOYSA-N
Quality Level 100 
SMILES string Clc1ccc2NC(=O)CSC(c3ccccc3Cl)c2c1
solubility DMSO: ≥20 mg/mL
storage temp. 2-8°C
Application: CGP-37157 has been used as a mitochondrial sodium-calcium exchanger (mNCX) inhibitor to study the role of normal mitochondrial calcium dynamics in sustaining dendritic spinogenesis.
Biochem/physiol Actions: Specific inhibitor of mitochondrial Na+/Ca2+ exchange as well as sarcoplasmic reticulum calcium-stimulated ATPase and possibly other calcium channels.
General description: CGP-37157 is a benzothiazepine compound, which is derived from clonazepam. It functions as a sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) antagonist and ryanodine receptor channels (RyR) agonist. CGP-37157 regulates intracellular signaling of calcium in smooth, cardiac and skeletal muscle cells and non-muscle systems.
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xn,N
Risk Statements 22-50
Safety Statements 61
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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