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Clofazimine

SIGMA/C8895

Synonym: N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine

CAS Number: 2030-63-9
Empirical Formula (Hill Notation): C27H22Cl2N4
Molecular Weight: 473.40
EC Number: 217-980-2
MDL Number: MFCD00056793
Linear Formula: C27H22Cl2N4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C8895-1G 1 g
 $59.30
1/EA		 Add To Favorites
45-C8895-5G 5 g
 $207.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C8895-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C8895-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C8895-5G

 

antibiotic activity spectrum mycobacteria
form powder
InChI 1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+
InChI key WDQPAMHFFCXSNU-BGABXYSRSA-N
mode of action protein synthesis | interferes
originator Novartis
Quality Level 200 
SMILES string CC(C)N=C1/C=C2N(c3ccc(Cl)cc3)c4ccccc4N=C2C=C1Nc5ccc(Cl)cc5
Application: Clofazimine has been used:
• for antimicrobial preparation
• to study its accumulation on macrophages to form crystal-like drug inclusions (CLDIs)
• to model drug-induced hepatic granulomatous inflammation
• to study the in vivo cargo storage capacity of macrophages
Features and Benefits: This compound was developed by Novartis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description: Clofazimine is a riminophenazine, which is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis. Clofazimine prevents neutrophil motility and lymphocyte transformation. It has anti-inflammatory effect, which is used to treat discoid lupus erythematosus. Clofazimine has immunosuppressive property.
Packaging: 1, 5 g in glass bottle
Preparation Note: This product is stored at room temperature.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
UNSPSC 12352200

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