Calpeptin
SIGMA/C8999 - ≥98% (HPLC)
Synonym: N-
CAS Number: 117591-20-5
Empirical Formula (Hill Notation): C20H30N2O4
Molecular Weight: 362.46
MDL Number: MFCD00155623
Linear Formula: C20H30N2O4
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C20H30N2O4/c1-4-5-11-1 |
| InChI key | PGGUOGKHUUUWAF-ROUUACIJSA |
| Quality Level | 100  |
| shipped in | wet ice |
| SMILES string | CCCC[C@H](NC(=O)[C@H](CC( |
| solubility | DMSO: 15 mg/mL, clear |
| storage temp. | −20°C |
| Application: | Calpeptin has been used as a calpain inhibitor. |
| Biochem/physiol Actions: | Calpeptin is a calpain inhibitor and rho kinase activator. |
| Biochem/physiol Actions: | Calpeptin is a rho kinase activator and an inhibitor of calpains, a family of calcium-dependent cysteine proteases involved in apoptosis, long-term potentiation in neurons, and cell cycle progression. |
| General description: | Calpeptin (Z-Leu-nLeu-H) is a cell permeable, peptide aldehyde inhibitor. It is more sensitive to calpain I compared to other inhibitors, such as Z-Leu-Met-H and leupeptin. Calpeptin stimulates neurite elongation in differentiating pheochromocytoma (PC12) cells. Calpeptin decreases microgliosis, astrogliosis, axonal damage and neuron and oligodendrocyte death in experimental autoimmune encephalomyelitis (EAE) spinal cord. Therefore, it can be considered as a potent therapeutic for treating EAE and multiple sclerosis (MS). |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |