Concanavalin A from Canavalia ensiformis (Jack bean)

SIGMA/C9017 - Sepharose^™ conjugate, buffered aqueous suspension

Synonym: ConA

Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-C9017-25ML	25 mL	$523.00 1/EA		Add To Favorites
45-C9017-100ML	100 mL	$1760.00 1/EA		Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

biological source	Canavalia ensiformis
capacity	≥25 mg/mL binding capacity (thyroglobulin)
conjugate	Sepharose^™ conjugate
contains	20% ethanol as preservative
extent of labeling	10-16 mg per mL
form	buffered aqueous suspension
matrix	Sepharose 4B
matrix activation	cyanogen bromide
matrix attachment	amino
matrix spacer	1 atom
Quality Level	200
storage temp.	2-8°C

Analysis Note:	Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, containing Ca²⁺ and Mn²⁺ of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C.
Application:	Used for the purification of glycoproteins containing mannose.
Biochem/physiol Actions:	Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca²⁺ and Mn²⁺ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.
Legal Information:	Sepharose is a trademark of Cytiva
Packaging:	25, 100 mL in glass bottle
Physical form:	Suspension in 0.1 M acetate buffer, pH 6.0, containing 1 M NaCl, and 1 mM each of CaCl₂ , MgCl₂, and MnCl₂

Symbol	GHS08
Signal word	Danger
Hazard statements	H317 - H334 - H361
Precautionary statements	P201 - P202 - P280 - P302 + P352 - P304 + P340 + P312 - P308 + P313
Hazard Codes	Xn
Risk Statements	63-10-42/43
Safety Statements	23-36/37-45
RIDADR	UN1170 - class 3 - PG 3 - Ethanol, solution
WGK Germany	WGK 3
Flash Point(F)	102.2 °F
Flash Point(C)	39 °C

Storage Temp.	2-8°C
UNSPSC	12161501

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