CK-869
SIGMA/C9124 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 388592-44-7
Empirical Formula (Hill Notation): C17H16BrNO3S
Molecular Weight: 394.28
MDL Number: MFCD01844129
Linear Formula: C17H16BrNO3S
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to light gray |
| form | powder |
| InChI | 1S/C17H16BrNO3S/c1-21-13- |
| InChI key | MVWNPZYLNLATCH-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | S1C(N(C(=O)C1)c3c(cc(cc3) |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | 2-8°C |
| Application: | CK-869 has been used as an Arp2/3 complex inhibitor: • to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly • to induce membrane blebbing in HT1080 fibrosarcoma cells • to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis |
| Biochem/physiol Actions: | CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex. |
| Biochem/physiol Actions: | CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast. |
| Biochem/physiol Actions: | CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast. The actin-related protein Arp2/3 complex plays a major role in the regulation of the actin cytoskeleton. Apparently the compound binds to the hydrophobic core of Arp3 and alters its conformation. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | N |
| Risk Statements | 50 |
| Safety Statements | 61 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |