Sodium cholate hydrate

SIGMA/C9282 - suitable for cell culture, BioReagent

Synonym: 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt; Cholalic acid sodium salt

CAS Number: 206986-87-0
Empirical Formula (Hill Notation): C₂₄H₃₉NaO₅ · xH₂O
Molecular Weight: 430.55 (anhydrous basis)
EC Number: 206-643-5
MDL Number: MFCD00150749
Linear Formula: C₂₄H₃₉NaO₅ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C9282-25G	25 g	$93.90 1/EA	Add To Favorites
45-C9282-100G	100 g	$248.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C9282-25G

Properties
Descriptions
Safety Info.
Basic Data

aggregation number	2-3
assay	≥99.0% (HPLC)
biological source	bovine bile
	ovine bile
CMC	9-15 mM (20-25°C)
description	anionic
form	powder
HLB	18
InChI	1S/C24H40O5.Na.H2O/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);;1H2/q;+1;/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;;/m1../s1
InChI key	MUVVIYFKOVLQHL-RCVKHMDESA-M
mol wt	micellar avg mol wt 900-1300
product line	BioReagent
Quality Level	200
SMILES string	O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C
solubility	water: 100 mg/mL, clear, colorless to light yellow
technique(s)	cell culture \| mammalian: suitable

Application:	Cholate is a bile acid produced in liver during cholesterol breakdown. Cholate downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis). Cholate, an anionic detergent, is used alone and in combination with urea to extract and reconstitute membrane proteins and protein complexes.
Application:	Sodium cholate hydrate has been used: • as a bile acid to induce bile acid-responsive (BEAR) transcription system, • as a component of Campylobacter defined broth (CDB) to test its effect on stress response in Campylobacter jejuni{52 • to test its sensitivity towards the bile acid sensor
Biochem/physiol Actions:	Reduction in 12-α hydroxylase activity leads to low levels of cholic acid in liver disease.
General description:	Cholate is a primary bile acid produced from cholesterol in the liver. It is an anionic detergent synthesized from cholesterol in the presence of sterol 12α-hydroxylase (CYP8B1).
Packaging:	25, 100 g in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99.0% (HPLC)
UNSPSC	12161902

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