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Cloxacillin sodium salt monohydrate

SIGMA/C9393 - β-lactamase-resistant antibiotic

Synonym: Cloxacillin; Sodium cloxacillin monohydrate

CAS Number: 7081-44-9
Empirical Formula (Hill Notation): C19H17ClN3NaO5S · H2O
Molecular Weight: 475.88
EC Number: 211-390-9
MDL Number: MFCD00150735
Linear Formula: C19H17ClN3O5SNa · H2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C9393-1G 1 g
 $66.60
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45-C9393-5G 5 g
 $268.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum Gram-positive bacteria
form powder or crystals
InChI 1S/C19H18ClN3O5S.Na.H2O/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1
InChI key KCUWTKOTPIUBRI-VICXVTCVSA-M
mode of action cell wall synthesis | interferes
Quality Level 200 
SMILES string O.[Na+].Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@H]3[C@H]4SC(C)(C)[C@@H](N4C3=O)C([O-])=O
storage temp. 2-8°C
Application: Cloxacillin is effective against infections caused by penicillin G-resistant staphylococci. It was used in studies of topical antibacterial agents for burn and crush wounds.
Biochem/physiol Actions: Cloxacillin is a semi-synthetic antibiotic and a chlorinated derivative of oxacillin. It inhibits the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Cloxacillin is often used as AmpC β-lactamase inhibitor in combination with β-lactam antibiotics.
General description: Chemical structure: ß-lactam
Other Notes: Keep container tightly closed in a dry and well-ventilated place.
Storage Temp. 2-8°C
UNSPSC 51102829

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