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Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride

SIGMA/C9521 - kallikrein substrate

Synonym: Z-Phe-Arg-AMC

CAS Number: 70382-26-2
Empirical Formula (Hill Notation): C33H36N6O6 · HCl
Molecular Weight: 649.14
MDL Number: MFCD00077030
Linear Formula: C33H36N6O6 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C9521-25MG 25 mg
 $595.00
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45-C9521-100MG 100 mg
 $2010.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C9521-100MG

 

assay ≥95% (HPLC)
concentration ≥95%
form powder
InChI 1S/C33H36N6O6/c1-21-17-29(40)45-28-19-24(14-15-25(21)28)37-30(41)26(13-8-16-36-32(34)35)38-31(42)27(18-22-9-4-2-5-10-22)39-33(43)44-20-23-11-6-3-7-12-23/h2-7,9-12,14-15,17,19,26-27H,8,13,16,18,20H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,34,35,36)
InChI key ZZGDDBWFXDMARY-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(NC2=CC=C(C(C)=CC(O3)=O)C3=C2)=O)=O)OCC4=CC=CC=C4.[Cl]
solubility methanol: 20 mg/mL, clear, colorless
storage temp. −20°C
Application: Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride has been used:
• as a fluorogenic substrate in actinidin inhibition assay
• as a kallikrein substrate
• as a trypsin substrate for fluorometric assay
• as a cathepsin-L substrate
Biochem/physiol Actions: Z-Phe-Arg 7-amido-4-methylcoumarin (Z-FR-AMC) proteolytic lysis by proteases leads to the liberation of AMC resulting in increased fluorescence in the enzymatic reaction.
General description: A fluorogenic substrate for plasma kallikrein.
General description: Z-Phe-Arg 7-amido-4-methylcoumarin (Z-FR-AMC) is a peptidomimetic substrate for papainand other enzymes such as cathepsin K. It is also a fluorogenic synthetic peptide for the enzymes cathepsins L and B.
Packaging: 100 mg in glass bottle
Packaging: 25 mg in glass insert
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352204

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