Carnosol
SIGMA/C9617
Synonym: Picrosalvin
CAS Number: 5957-80-2
Empirical Formula (Hill Notation): C20H26O4
Molecular Weight: 330.42
MDL Number: MFCD02752467
Linear Formula: C20H26O4
Product Type: Chemical
| application(s) | metabolomics vitamins, nutraceuticals, and natural products |
| biological source | Rosemarinus officinalis L. |
| form | powder |
| InChI | 1S/C20H26O4/c1-10(2)11-8- |
| InChI key | XUSYGBPHQBWGAD-PJSUUKDQSA |
| Quality Level | 200  |
| shipped in | dry ice |
| SMILES string | CC(C)c1cc2[C@@H]3C[C@H]4C |
| storage temp. | −20°C |
| Application: | Carnosol has been used as an anti-cancer agent: • to test its anti-cancer and anti-proliferative activities on cancer stem-like cells (CSCs) and Glioblastoma multiforme (GBM) cells • to inspect its anti-carcinogenic effects on nineteen genes involved in up-and down-regulation of different genetic carcinogenesis pathways and on HeLa cells in human cervical cancer model • as a reference standard to identify and quantify the metabolites of rosemary extract using liquid chromatography coupled to tandem mass spectrometry (LC/ESI-MS/MS) |
| Biochem/physiol Actions: | A phenolic diterpene with antioxidant and anticarcinogenic activities. |
| Biochem/physiol Actions: | Carnosol together with carnosic acid (CA) accounts for 90% of the antioxidant activity of rosemary leaves. It exerts neuroprotective properties and protects against neuroinflammation, and oxidative stress-induced brain damage under chronic stress conditions. Carnosol is a strong chemo-therapeutic agent studied for several types of cancer like breast, leukemia, skin, prostate, and colon. It is also an antimicrobial agent. |
| General description: | Carnosol (CAR) is an ortho-diphenolic diterpene, extracted from the Mediterranean dietary herb Rosmarinus officinalis L. (rosemary). It was first isolated from the Salvia carnosa (Sage) plant. Carnosol is also a pro-electrophilic molecule. |
| Packaging: | 5 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P280 - P302 + P352 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352100 |