Chetomin
SIGMA/C9623 - from Chaetomium cochliodes, ≥98% (HPLC)
Synonym: Chaetomin; NSC 289491
CAS Number: 1403-36-7
Empirical Formula (Hill Notation): C31H30N6O6S4
Molecular Weight: 710.87
MDL Number: MFCD28137713
Linear Formula: C31H30N6O6S4
Product Type: Chemical
| assay | ≥98% (HPLC) |
| biological source | Chaetomium cochliodes |
| form | powder |
| InChI | 1S/C31H30N6O6S4/c1-33-25( |
| InChI key | ZRZWBWPDBOVIGQ-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | S1SC9(N(C(=O)C1(N(C9=O)C) |
| solubility | acetone: soluble |
| DMSO: soluble | |
| ethyl acetate: soluble | |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin disrupts the hypoxia-inducible factor (HIF) pathway, blockomg the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth; hypoxia can also promote resistance to radiotherapeutics. By both of these mechanisms, chetomin shows promise as a lead compound in antitumor research. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes. |
| Biochem/physiol Actions: | Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes. |
| Biochem/physiol Actions: | Chetomin is a natural metabolite, which blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes. |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P310 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 41100000 |