Chorionic gonadotropin human
SIGMA/CG5 - lyophilized powder, vial of ~5,000 IU
Synonym: Choriogonin; HCG
CAS Number: 9002-61-3
EC Number: 232-660-2
MDL Number: MFCD00130797
Product Type: Chemical
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| biological source | human urine |
| contains | mannitol |
| drug control | Home Office Schedule 4.2 |
| form | lyophilized powder |
| impurities | HBsAg, HCV and HIV-1/HIV-2, tested negative |
| mol wt | 37.9 kDa |
| packaging | vial of ~5,000 IU |
| Quality Level | 200  |
| shipped in | ambient |
| solubility | water: 10 mL/vial, clear to slightly hazy, colorless |
| sterility | sterile-filtered |
| storage temp. | −20°C |
| UniProt accession no. | P01215  |
| Analysis Note: | The calculated value is based on the USP method for human Chorionic Gonadotrophin, to meet 5,000 IU per vial, with a tolerance of not less than 80.0% and not more than 125.0% of the potency stated. |
| Application: | Chorionic gonadotropin human has been used: • to induce oocyte maturation in cultured follicles • along with pregnant mare serum gonadotropin (PMSG) to induce superovulation in mice • as medium component for fetal testes culture to aid steroidogenic responsiveness |
| Biochem/physiol Actions: | Elevated levels of hCG is observed in trophoblastic cancer. hCG levels are indicators of pregnancy and β subunit is majorly present in urine samples. hCG isoform detection is useful in the diagnosis and management of trophoblastic related diseases including carcinomas. |
| General description: | Chorionic gonadotropin human (CGA or hCG) is a heterodimer and belongs to the cystine knot growth factor superfamily. It exists as six variants namely hCGn, hCGβ, hCGβn, hCGβcf and hCGα including hCG. CGA is mapped to human chromosome 6q14.3. hCG comprises of α and β chain. |
| General description: | Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG. |
| Preparation Note: | When reconstituted with water to a concentration of 1,000 IU/mL, the vial will also contain 0.02 M sodium phosphate buffer (pH approx. 7.2) and 20 mg/mL of mannitol. |
| Symbol |  GHS08 |
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 63-62 |
| Safety Statements | 36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352209 |