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Deoxynivalenol

SIGMA/D0156

Synonym: 3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one; Vomitoxin

CAS Number: 51481-10-8
Empirical Formula (Hill Notation): C15H20O6
Molecular Weight: 296.32
MDL Number: MFCD09039270
Linear Formula: C15H20O6
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-D0156-1MG 1 mg
$127.00
1/EA
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45-D0156-5MG 5 mg
$433.00
1/EA
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form powder
InChI 1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
InChI key LINOMUASTDIRTM-QGRHZQQGSA-N
Quality Level 300 
SMILES string [H][C@]12O[C@]3([H])[C@H](O)C[C@@](C)([C@]34CO4)[C@@]1(CO)[C@H](O)C(=O)C(C)=C2
storage temp. 2-8°C
Application: Deoxynivalenol has been used:

• as a mycotoxin to induce cytotoxicity in porcine jejunal epithelial cells and study the protective effects of Saccharomyces cerevisiae on the cell viability of host cells.
• to induce toxicity in nude mice to study the effect of probiotics (Lactobacillus rhamnosus GG (LGG) or Lactobacillus acidophilus (LA)) supplementation on host protection
• as a thyroid hormone receptor (TRβ) antagonist in cell-based luciferase reporter gene (CALUX) assay
Biochem/physiol Actions: Deoxynivalenol (DON) blocks the synthesis of DNA and RNA by inhibiting the process of translation.
General description: Deoxynivalenol (DON) is a natural mycotoxin found in Fusarium graminearum and Fusarium culmorum. It belongs to the B-trichothecenes family of mycotoxins.
Packaging: 1, 5 mg in serum bottle
Storage Temp. 2-8°C
UNSPSC 12352200

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