Synonym: (5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1α,3β-diol; (5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol; 1α-Hydroxyergocalciferol; 1α-Hydroxyvitamin D2; 1α-OHD2; 1-α-Hydroxyvitamin D2; 1-Hydroxyergocalciferol; TSA 840
CAS Number: 54573-75-0
Empirical Formula (Hill Notation): C28H44O2
Molecular Weight: 412.65
MDL Number: MFCD00871065
Linear Formula: C28H44O2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| form |
powder |
| InChI |
1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1 |
| InChI key |
HKXBNHCUPKIYDM-CGMHZMFXSA-N |
| Quality Level |
100  |
| shipped in |
wet ice |
| SMILES string |
CC(C)[C@@H](C)C=C[C@@H](C)[C@H]1CC[C@H]2C(CCC[C@]12C)=CC=C3C[C@@H](O)C[C@H](O)C3=C |
| solubility |
DMSO: >10 mg/mL |
| storage condition |
desiccated |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
Doxercalciferol is a Vitamin D2 analogue, a Vitamin D Receptor Activator (VDRA). |
| Biochem/physiol Actions: |
Doxercalciferol is a Vitamin D2 analogue, a Vitamin D Receptor Activator (VDRA). Doxercalciferol acts as a pro-hormone, needing 25-hydroxylation in the liver for bioactivation into 1α, 25-hydroxyvitamin D2. Pivotal studies in adults on dialysis have demonstrated control of secondary hyperparathyroidism that is superior to placebo therapy, without undue suppression of 1st IMA-PTH < 300 pg/mL, or occurrences of hypercalcemia. Doxercalciferol has been shown to be effective in controlling secondary hyperparathyroidism of adult patients with CKD stages 3-4. |
| Biochem/physiol Actions: |
Doxercalciferol is a vitamin D2 analog that acts as a pro-hormone, activated in the liver to 1α,25-dihydroxyvitamin D2. |
| Biochem/physiol Actions: |
Doxercalciferol is a vitamin D2 analog that acts as a pro-hormone, activated in the liver to 1α,25-dihydroxyvitamin D2. Despite its relatively low affinity for the vitamin D receptor (VDR) (before activation), it is effective at suppressing expression of the parathyroid hormone (PTH) gene, and appears to act through the VDR. |
| Packaging: |
1, 5 mg in glass bottle |
| Symbol |
 GHS06 |
| Signal word |
Danger |
| Hazard statements |
H300 |
| Precautionary statements |
P264 - P301 + P310 |
| Hazard Codes |
T+ |
| Risk Statements |
28 |
| Safety Statements |
28-36/37-45 |
| RIDADR |
UN 2811 6.1 / PGIII |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
