Doxercalciferol

SIGMA/D0196 - ≥98% (HPLC), solubility: >10 mg/mL in DMSO

Synonym: (5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1α,3β-diol; (5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol; 1α-Hydroxyergocalciferol; 1α-Hydroxyvitamin D₂; 1α-OHD2; 1-α-Hydroxyvitamin D2; 1-Hydroxyergocalciferol; TSA 840

CAS Number: 54573-75-0
Empirical Formula (Hill Notation): C₂₈H₄₄O₂
Molecular Weight: 412.65
MDL Number: MFCD00871065
Linear Formula: C₂₈H₄₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-D0196-1MG	1 mg	$142.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
form	powder
InChI	1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1
InChI key	HKXBNHCUPKIYDM-CGMHZMFXSA-N
Quality Level	100
shipped in	wet ice
SMILES string	CC(C)[C@@H](C)C=C[C@@H](C)[C@H]1CC[C@H]2C(CCC[C@]12C)=CC=C3C[C@@H](O)C[C@H](O)C3=C
solubility	DMSO: >10 mg/mL
storage condition	desiccated
storage temp.	−20°C

Biochem/physiol Actions:	Doxercalciferol is a Vitamin D2 analogue, a Vitamin D Receptor Activator (VDRA).
Biochem/physiol Actions:	Doxercalciferol is a Vitamin D2 analogue, a Vitamin D Receptor Activator (VDRA). Doxercalciferol acts as a pro-hormone, needing 25-hydroxylation in the liver for bioactivation into 1α, 25-hydroxyvitamin D2. Pivotal studies in adults on dialysis have demonstrated control of secondary hyperparathyroidism that is superior to placebo therapy, without undue suppression of 1st IMA-PTH < 300 pg/mL, or occurrences of hypercalcemia. Doxercalciferol has been shown to be effective in controlling secondary hyperparathyroidism of adult patients with CKD stages 3-4.
Biochem/physiol Actions:	Doxercalciferol is a vitamin D₂ analog that acts as a pro-hormone, activated in the liver to 1α,25-dihydroxyvitamin D₂.
Biochem/physiol Actions:	Doxercalciferol is a vitamin D₂ analog that acts as a pro-hormone, activated in the liver to 1α,25-dihydroxyvitamin D₂. Despite its relatively low affinity for the vitamin D receptor (VDR) (before activation), it is effective at suppressing expression of the parathyroid hormone (PTH) gene, and appears to act through the VDR.
Packaging:	1, 5 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P264 - P301 + P310
Hazard Codes	T+
Risk Statements	28
Safety Statements	28-36/37-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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