Advanced Search



MPP+ iodide

SIGMA/D048 - ≥98% (HPLC), powder

Synonym: 1-Methyl-4-phenylpyridinium iodide

CAS Number: 36913-39-0
Empirical Formula (Hill Notation): C12H12IN
Molecular Weight: 297.13
MDL Number: MFCD00055096
Linear Formula: C12H12IN
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D048-100MG 100 mg
 $200.00
1/EA		 Add To Favorites
45-D048-1G 1 g
 $1190.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D048-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D048-1G

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
InChI key RFDFRDXIIKROAI-UHFFFAOYSA-M
Quality Level 100 
SMILES string [I-].C[n+]1ccc(cc1)-c2ccccc2
solubility H2O: 10 mg/mL, clear
storage condition desiccated
Application: MPP+ iodide has been used:
• to induce oxidative stress in zebrafish embryos
• for the inhibition of glutamate uptake in mitochondria of astrocytes
• in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells
Biochem/physiol Actions: Active metabolite of dopaminergic neurotoxin MPTP
Biochem/physiol Actions: MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.
Disclaimer: Photosensitive.
General description: 1-Methyl-4-phenylpyridinium (MPP+) acts as a selective ERα antagonist.induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.
Other Notes: 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research 
Packaging: 1 g in glass bottle
Packaging: 100 mg in glass bottle
Preparation Note: Solutions should be freshly prepared.
Purity ≥98% (HPLC)
UNSPSC 12352200

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Tariffs & Effects on Pricing

Tariff note: As we navigate the current environment of tariff surcharges and mid-year manufacturer price increases, we want to keep you informed. While we have avoided making specific decisions thus far, we anticipate that we will be forced to implement a cost adjustment policy to offset the fees we have already been absorbing. We are committed to transparency and moderation in this process.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top