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GBR 12909 dihydrochloride

SIGMA/D052 - solid, ≥98% (HPLC)

Synonym: 1-(2-[bis(4-Fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride

CAS Number: 67469-78-7
Empirical Formula (Hill Notation): C28H32F2N2O · 2HCl
Molecular Weight: 523.49
MDL Number: MFCD00055193
Linear Formula: C28H32F2N2O · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D052-25MG 25 mg
 $316.00
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45-D052-100MG 100 mg
 $753.00
1/EA		 Add To Favorites
45-D052-250MG 250 mg
 $1520.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D052-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D052-250MG

 

assay ≥98% (HPLC)
color white
form solid
InChI 1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
InChI key MIBSKSYCRFWIRU-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.Cl.Fc1ccc(cc1)C(OCCN2CCN(CCCc3ccccc3)CC2)c4ccc(F)cc4
solubility DMSO: >5 mg/mL (Solutions freshly prepared daily)
storage condition desiccated
Application: GBR 12909 dihydrochloride has been used as a dopamine transporter (DAT) inhibitor:

• to study its effects on LPS-induced mRNA expression on the proinflammatory cytokines in the mouse striatum
• to study its effects on neurotransmitter release in zebrafish brain
• in DA uptake assay in mice striatal fraction
Biochem/physiol Actions: GBR 12909 is a highly selective dopamine reuptake inhibitor with behavioral effects similar to cocaine.
Biochem/physiol Actions: GBR 12909 may show pharmacotherapeutic effects against cocaine addiction.
Features and Benefits: This compound is featured on the Biogenic Amine Transporters  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 25, 100, 250 mg in poly bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
UNSPSC 12352200

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