R(+)-SCH-23390 hydrochloride
SIGMA/D054 - ≥98% (HPLC), solid
Synonym: R(+)
CAS Number: 125941-87-9
Empirical Formula (Hill Notation): C17H18ClNO · HCl
Molecular Weight: 324.24
MDL Number: MFCD00069249
Linear Formula: C17H18ClNO · HCl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white |
| form | solid |
| InChI | 1S/C17H18ClNO.ClH/c1-19-8 |
| InChI key | OYCAEWMSOPMASE-XFULWGLBSA |
| optical activity | [α]/D +32.1°, c = 1 in DMF(lit.) |
| Quality Level | 100  |
| SMILES string | Cl[H].CN1CCc2cc(Cl)c(O)cc |
| solubility | H2O: >5 mg/mL |
| storage condition | desiccated |
| protect from light |
| Application: | R(+)-SCH-23390 hydrochloride has been used: • for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization • as a D1 receptor-selective antagonist for intracranial drug infusions • as an antagonist of D1 receptor to study its effect on learning ability in fish |
| Biochem/physiol Actions: | R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity. |
| Features and Benefits: | This compound is featured on the Dopamine Receptors and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Legal Information: | Sold with the permission of Schering-Plough. |
| Packaging: | 5, 10, 25, 100 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| UNSPSC | 12352200 |