DIF-3
SIGMA/D0567 - ≥99% (HPLC), solid
Synonym: 1-
CAS Number: 113411-17-9
Empirical Formula (Hill Notation): C13H17ClO4
Molecular Weight: 272.72
MDL Number: MFCD05865230
Linear Formula: C13H17ClO4
Product Type: Chemical
| assay | ≥99% (HPLC) |
| form | solid |
| InChI | 1S/C13H17ClO4/c1-3-4-5-6- |
| InChI key | JWBMZIJMSBFBIY-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CCCCCC(=O)c1c(O)cc(OC)c(C |
| solubility | DMSO: soluble 46 mg/mL |
| Application: | DIF-3 has been used: as a glycogen synthase kinase-3β (GSK-3β) activator to determine if GSK-3β is required for the anti-inflammatory actions of VU0360172 (VuPAM) in murine microglia, as a phosphorylation inhibitor for GSK-3β to examine the links between activation of protein kinase B (PKB)/GSK-3β/Fyn axis and nuclear factor erythroid 2–related factor 2 (NRF2) retention, as a GSK3β activator to study its effects on the cyclooxygenase 2 (COX2) expression levels in human primary chondrocytes in response to visfatin, as a GSK3β activator to study its effects on the intracellular mechanics along with F-actin and β-tubulin fiber networks in human primary chondrocytes |
| Biochem/physiol Actions: | DIF-3 Inhibits cell cycle by inducing G0/G1 arrest. |
| Biochem/physiol Actions: | Differentiation-inducing factor-3 (DIF-3) prevents the proliferation of intestinal cancer cells in vitro and in vivo. It may serve as a novel anti-cancer agent. |
| General description: | Differentiation-inducing factor-3 (DIF-3) is a monochlorinated metabolite of differentiation-inducing factor-1 (DIF-1), that belongs to the differentiation-inducing factor (DIF) family. |
| Packaging: | 1 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% (HPLC) |
| UNSPSC | 12352200 |