Dihydrotanshinone I
SIGMA/D0947 - ≥98% (HPLC)
Synonym: Dihydrotanshinone I; (-
CAS Number: 87205-99-0
Empirical Formula (Hill Notation): C18H14O3
Molecular Weight: 278.30
MDL Number: MFCD28016070
Linear Formula: C18H14O3
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D0947-10MG.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: D0947-50MG
This image depicts SKU: D0947-50MG
| application(s) | metabolomics vitamins, nutraceuticals, and natural products |
| assay | ≥98% (HPLC) |
| biological source | Salvia miltiorrhiza |
| color | red |
| form | powder |
| InChI | 1S/C18H14O3/c1-9-4-3-5-12 |
| InChI key | HARGZZNYNSYSGJ-JTQLQIEISA |
| Quality Level | 200  |
| SMILES string | C[C@H]1COC(C2=C3C4=C(C=C2 |
| solubility | ethanol: 1 mg/mL, clear, orange to red |
| storage condition | protect from light |
| storage temp. | 2-8°C |
| Application: | Dihydrotanshinone I (DHTS) has been used: • to study its cytocidal effects on chemosensitive ovarian cancer cells with or without platinum-based chemotherapy • as a treatment to study its inhibitory effects on triple-negative breast cancer cells growth by modulating epithelial-mesenchymal transition (EMT) markers • as a potential SARS-CoV-2 papain-like protease (PLpro) inhibitor • as a human antigen R (HuR) inhibitor to study its role in Th17 cell differentiation related to autoimmune neuroinflammation • as a reference standard to analyze Salvia miltiorrhiza Bunge extract (SME) components using high-performance liquid chromatography(HPLC) |
| Biochem/physiol Actions: | Dihydrotanshinone Iis a potent anti-cancer agent with its cytotoxic, apoptosis, cell cycle arresteffects and inhibition of angiogenesis, and metastasis in cancer cells. Italso exerts cardiovascular and cerebrovascular protective effects. DHTS isan anti-inflammatory, anti-ischemia-reperfusion (I/R), anti-allergic,anti-Alzhei |
| Biochem/physiol Actions: | Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with mouse xenograft model. |
| General description: | DihydrotanshinoneI (DHTS) is a tanshinone derivative which is a soluble diterpene quinone pigment of danshen. |
| Packaging: | 10 mg in glass bottle |
| Packaging: | 50 mg in poly bottle |
| Hazard Codes | Xn,N |
| Risk Statements | 22-50 |
| Safety Statements | 61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |