Synonym: 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine; Clarinex®; NSC 675447
CAS Number: 100643-71-8
Empirical Formula (Hill Notation): C19H19ClN2
Molecular Weight: 310.82
MDL Number: MFCD00871949
Linear Formula: C19H19ClN2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| form |
powder |
| InChI |
1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2 |
| InChI key |
JAUOIFJMECXRGI-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
Clc1ccc2c(CCc3cccnc3C2=C4CCNCC4)c1 |
| solubility |
DMSO: >10 mg/mL |
| storage temp. |
2-8°C |
| Application: |
Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells. It has also been used as an antihistamine mimic in rats and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies. |
| Biochem/physiol Actions: |
A non-sedating H1-receptor antagonist, free from antimuscarinic/anticholinergic effects. It has novel antiallergic and anti-inflammatory effects. |
| Biochem/physiol Actions: |
Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects. |
| Legal Information: |
Clarinex is a registered trademark of Schering Corp. |
| Packaging: |
10, 50 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
