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R-(+)-DIOA

SIGMA/D129 - ≥98% (HPLC), solid

Synonym: R(+)-Butylindazone; R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid

CAS Number: 81166-47-4
Empirical Formula (Hill Notation): C20H24Cl2O4
Molecular Weight: 399.31
MDL Number: MFCD00069261
Linear Formula: C20H24Cl2O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D129-10MG 10 mg
 $352.00
1/EA		 Add To Favorites
45-D129-50MG 50 mg
 $1150.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
form solid
InChI 1S/C20H24Cl2O4/c1-2-3-8-20(13-6-4-5-7-13)10-12-9-14(26-11-15(23)24)17(21)18(22)16(12)19(20)25/h9,13H,2-8,10-11H2,1H3,(H,23,24)/t20-/m0/s1
InChI key YAWWQIFONIPBKT-FQEVSTJZSA-N
optical activity [α]27/D +18.1°, c = 0.7 in methanol(lit.)
Quality Level 100 
SMILES string CCCC[C@]1(Cc2cc(OCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3
solubility 0.1 M HCl: insoluble
  0.1 M NaOH: soluble
  DMSO: >20 mg/mL
  ethanol: soluble
  H2O: insoluble <0.11 mg/mL
Application: R-(+)-DIOA has been used as a potassium/chloride K+-Cl- transport inhibitor to study its effects on:
• short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
• uptake of grepafloxacin by THP-1 monocytes
• the uptake of moxifloxacin by THP-1 monocytes
Biochem/physiol Actions: [(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl−) co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system.
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
UNSPSC 12352200

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