Synonym: 1-(2,3-Dideoxy-β-D-glycero-pent-2-enofuranosyl)thymine; 1-[(2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-(1H,3H)-dione; 2′,3′-Anhydrothymidine; Stavudine; d4T
CAS Number: 3056-17-5
Empirical Formula (Hill Notation): C10H12N2O4
Molecular Weight: 224.21
MDL Number: MFCD00132921
Linear Formula: C10H12N2O4
Product Type: Chemical
| assay |
≥98% (TLC) |
| form |
powder |
| InChI |
1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1 |
| InChI key |
XNKLLVCARDGLGL-JGVFFNPUSA-N |
| Quality Level |
200  |
| SMILES string |
CC1=CN([C@@H]2O[C@H](CO)C=C2)C(=O)NC1=O |
| storage temp. |
−20°C |
| Application: |
2′,3′-Didehydro-3′-deoxythymidine has been used in cell treatment. It has also been used as a drug in Caenorhabditis elegans to study drug induced mitochondrial toxicity. It has also been used in the preclinical evaluation of GS-9160. |
| Biochem/physiol Actions: |
2′,3′-Didehydro-3′-deoxythymidine is a nucleoside analog, which inhibits HIV replication in vitro. Stavudine has the ability to enter the cells by non-facilitated diffusion. It possesses inhibitory activity against moloney murine leukemia virus, friend murine leukemia virus and simian immunodeficiency virus. |
| General description: |
2′,3′-Didehydro-3′-deoxythymidine (d4T), a pyrimidine analogue is the inhibitor of reverse transcriptase. |
| Packaging: |
10, 50 mg in poly bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 2 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (TLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
