4,6-Dioxoheptanoic acid
SIGMA/D1415 - powder
Synonym: Succinylacetone
CAS Number: 51568-18-4
Empirical Formula (Hill Notation): C7H10O4
Molecular Weight: 158.15
MDL Number: MFCD00002797
Linear Formula: CH3COCH2COCH2CH2CO2H
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D1415-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D1415-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D1415-500MG
| form | powder |
| InChI | 1S/C7H10O4/c1-5(8)4-6(9)2 |
| InChI key | WYEPBHZLDUPIOD-UHFFFAOYSA |
| lipid type | saturated FAs |
| mp | 66-67 °C (lit.) |
| Quality Level | 200  |
| SMILES string | CC(=O)CC(=O)CCC(O)=O |
| storage temp. | 2-8°C |
| Application: | 4,6-Dioxoheptanoic acid has been used: • as component of dendritic cell conditioning medium and in the inhibition of ALA dehydratase (ALAD) in dendritic cells(50) • as an inhibitor of heme biosynthesis in human mononuclear cells(51) and HeLa cells(52) • as a standard for the quantification of succinylacetone from Plasmodium falciparum cultures(53) |
| Biochem/physiol Actions: | 4,6-Dioxoheptanoic acid is an inhibitor of heme biosynthesis. It is a catabolic byproduct of tyrosine breakdown and inhibits δ-aminolevulinic acid (ALA) dehydratase enzyme. It is a potential marker for detecting tyrosinemia type I and is measured in dried blood spot of new borns. |
| Biochem/physiol Actions: | An inhibitor of heme biosynthesis |
| Packaging: | 1 g in glass bottle |
| Packaging: | 100, 500 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 66-67 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352211 |