Dexrazoxane

SIGMA/D1446 - ≥95% (HPLC)

Synonym: (+)-(S)-4,4′-Propylenedi-2,6-piperazinedione; (S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; Cardioxane; ICRF-187; NSC169780; Zinecard

CAS Number: 24584-09-6
Empirical Formula (Hill Notation): C₁₁H₁₆N₄O₄
Molecular Weight: 268.27
MDL Number: MFCD00866449
Linear Formula: C₁₁H₁₆N₄O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-D1446-5MG	5 mg	$117.00 1/EA	Add To Favorites
45-D1446-25MG	25 mg	$462.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
color	white to off-white
form	powder
InChI	1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
InChI key	BMKDZUISNHGIBY-ZETCQYMHSA-N
originator	Johnson & Johnson
Quality Level	100
SMILES string	C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
solubility	DMSO: >20 mg/mL
storage temp.	room temp

Application:	Dexrazoxane has been used in chromatin remodelling experiments.
Biochem/physiol Actions:	Dexrazoxane is a cardioprotective compound against anthracyclines. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.
Biochem/physiol Actions:	Dexrazoxane is a cardioprotective compound used to counteract the effects of anthracyclines. Dexrazoxane is believed to function as a free radical scanenger.
Features and Benefits:	This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Dexrazoxane is a member of bis(2,6-dioxopiperazines), that functions as a topoisomerase 2 catalytic inhibitor. Dexrazoxane is a free radical scavenger. It might protect the heart from doxorubicin-associated damage. Dexrazoxane acts as a cardiopulmonary protectant, while treating Hodgkin′s disease (HD). It functions as a chelating agent, which limits the formation of anthracycline-iron complexes. It is used to synthesize antimalarial drugs.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

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