Synonym: (+)-(S)-4,4′-Propylenedi-2,6-piperazinedione; (S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; Cardioxane; ICRF-187; NSC169780; Zinecard
CAS Number: 24584-09-6
Empirical Formula (Hill Notation): C11H16N4O4
Molecular Weight: 268.27
MDL Number: MFCD00866449
Linear Formula: C11H16N4O4
Product Type: Chemical
| assay |
≥95% (HPLC) |
| color |
white to off-white |
| form |
powder |
| InChI |
1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1 |
| InChI key |
BMKDZUISNHGIBY-ZETCQYMHSA-N |
| originator |
Johnson & Johnson |
| Quality Level |
100  |
| SMILES string |
C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2 |
| solubility |
DMSO: >20 mg/mL |
| storage temp. |
room temp |
| Application: |
Dexrazoxane has been used in chromatin remodelling experiments. |
| Biochem/physiol Actions: |
Dexrazoxane is a cardioprotective compound against anthracyclines. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane. |
| Biochem/physiol Actions: |
Dexrazoxane is a cardioprotective compound used to counteract the effects of anthracyclines. Dexrazoxane is believed to function as a free radical scanenger. |
| Features and Benefits: |
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: |
This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: |
Dexrazoxane is a member of bis(2,6-dioxopiperazines), that functions as a topoisomerase 2 catalytic inhibitor. Dexrazoxane is a free radical scavenger. It might protect the heart from doxorubicin-associated damage. Dexrazoxane acts as a cardiopulmonary protectant, while treating Hodgkin′s disease (HD). It functions as a chelating agent, which limits the formation of anthracycline-iron complexes. It is used to synthesize antimalarial drugs. |
| Packaging: |
5, 25 mg in glass bottle |
| Purity |
≥95% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
12352200 |
GHS07