1α,25-Dihydroxyvitamin D₃

SIGMA/D1530 - ≥99% (HPLC)

Synonym: 1α,25-Dihydroxycholecalciferol; Calcitriol

CAS Number: 32222-06-3
Empirical Formula (Hill Notation): C₂₇H₄₄O₃
Molecular Weight: 416.64
EC Number: 250-963-8
MDL Number: MFCD00867079
Linear Formula: C₂₇H₄₄O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-D1530-10UG	10 µg	$233.00 1/EA		Add To Favorites
45-D1530-.1MG	0.1 mg	$1060.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99% (HPLC)
form	solid
InChI	1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
InChI key	GMRQFYUYWCNGIN-NKMMMXOESA-N
Quality Level	300
SMILES string	[H][C@@]1(CC[C@@]2([H])C(CCC[C@]12C)=CC=C3C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O
storage temp.	−20°C
technique(s)	HPLC: suitable

Application:	1α,25-Dihydroxyvitamin D3 has been used as a supplement:• to study its effects on endothelial functions in high glucose-conditioned human umbilical vein endothelial cells (HUVECs) • to study the  osteogenic effect of bone morphogenetic protein-2 (BMP2) in human bone marrow-derived mesenchymal stem cells (hMSCs) • in osteogenic differentiation medium for osteogenic differentiation of  bone marrow-derived mesenchymal stem cells (BM-MSCs)
Biochem/physiol Actions:	Biologically active form of vitamin D₃in calcium absorption and deposition.
Biochem/physiol Actions:	Biologically active form of vitamin D₃in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D₃ has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D₃ acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.
Biochem/physiol Actions:	Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H300 + H310 + H330 - H372
Precautionary statements	P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
RIDADR	UN 2811 6.1 / PGI
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352205

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