Dextran from Leuconostoc mesenteroides

SIGMA/D1662 - average mol wt 35,000-45,000

Synonym: 6-O-(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)-D-glucose; Manninotriose

CAS Number: 9004-54-0
EC Number: 232-677-5
MDL Number: MFCD00130935
Linear Formula: (C₆H₁₀O₅)_n
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-D1662-10G	10 g	$65.30 1/EA	Add To Favorites
45-D1662-50G	50 g	$306.00 1/EA	Add To Favorites
45-D1662-100G	100 g	$407.00 1/EA	Add To Favorites
45-D1662-500G	500 g	$1530.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: D1662-50G

Properties
Descriptions
Safety Info.
Basic Data

application(s)	advanced drug delivery cell analysis ( ) life science and biopharma solubility enhancement
biological source	bacterial (Leuconostoc mesenteroides)
color	white
form	powder
InChI	1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2
InChI key	FZWBNHMXJMCXLU-UHFFFAOYSA-N
mol wt	average mol wt 35,000-45,000
optical activity	[α]/D 199°
Quality Level	200
SMILES string	O1C(C(C(C(C1CO)O)O)O)OCC2OC(C(C(C2O)O)O)OCC(O)C(O)C(O)C(O)C=O
solubility	H₂O: 100 mg/mL, clear, colorless
technique(s)	cell based assay: suitable
	cryopreservation: suitable

Application:	Dextrans are used in many applications as platelet aggregants, plasma volume extenders, osmotic pressure regulators, stabilizers, organ separation media, matrix components, copolymers, microcarriers, binding agents, viscosity modifiers, antithrombotics, lubricants and physical structure components. Dextrans may be used as long hydrophilic spacer arms to improve the performance (freedom of movement) of conjugated/bound proteins. Dextrans may be derivatized for use in biosensor systems. Dextran 40 may be derivatized for use as a cell permeation reagent. Further, dextrans can also be used for vector biology and disease control research, for cryopreservation, and also as an enhancer for controlled drug delivery studies
Application:	Use of dextrans as long and hydrophilic spacer arms improves the performance of immobilized proteins acting on macromolecules.
Biochem/physiol Actions:	• Osmotic Balance: Dextran helps maintain osmotic balance by increasing the solute concentration in a solution. This prevents excessive water movement across cell membranes, thus maintaining cell integrity and function. • Cryoprotection: Dextran acts as a cryoprotectant by forming a protective barrier around cells and tissues during freezing. This barrier inhibits the formation of ice crystals, which can damage cell membranes and structures. • Viscosity Control: Dextran can alter the viscosity of solutions by increasing the molecular weight of the solution. This change in viscosity affects the flow properties of the solution, making it useful in controlling the thickness of solutions in various processes. • Drug Delivery: Modified dextran serves as a carrier for controlled drug delivery. Dextran can encapsulate drugs and release them gradually, enhancing drug solubility and controlling the release profiles to improve therapeutic outcomes. • Gel Electrophoresis: Dextran increases the density of sample-loading solutions in gel electrophoresis. This increased density helps samples sink into the gel matrix, allowing for more precise separation of molecules based on size and charge during electrophoresis. • Enzyme Stabilization: Dextran stabilizes enzymes by providing a protective environment. It forms a stable matrix around enzymes, enhancing their activity and extending their lifespan in various biochemical reactions. This protection prevents enzyme denaturation and inactivation, allowing enzymes to function more effectively.
Features and Benefits:	• Dextran with an average molecular weight range of 35,000-45,000. • Freely soluble in Water, DMSO, formamide, ethylene glycol, and glycerol • Versatile and adaptable for various laboratory and research applications.
General description:	Dextrans are a class of polysaccharides primarily composed of glucose units, specifically, D-glucose units connected by alpha-(1-6) linkages. A Dextran is characterized by its high molecular weight, and its specific structure can vary depending on the microbial strain responsible for its production. These homopolysaccharides are created through the action of extracellular dextransucrase enzymes, typically found in lactic acid bacteria genera like Leuconostoc, Lactobacillus, Streptococcus, Weissella, and Pediococcus. Due to their versatile properties, they′re used in biochemical, cell culture, drug delivery research and gel electrophoresis applications.
Other Notes:	For additional information on our range of Biochemicals , please complete this form .
Other Notes:	Similar to D4133, but from another supplier.
Other Notes:	To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.
Packaging:	10, 50, 100, 500 g in poly bottle
Preparation Note:	With the exception of the highest MW dextran, D5501 (MW range = 5 million to 40 million), dextrans are very water soluble. Sigma tests the solubility of dextrans at concentrations generally exceeding 30 mg/ml in water. Dextrans are also freely soluble in DMSO, formamide, ethylene glycol, and glycerol. Neutral-aqueous dextran solutions can be sterilized by autoclaving at 110-115^oC for 30 to 45 minutes. Dextran can be hydrolyzed by strong acids at high temperatures. The terminal reducing end group of dextran can be oxidized in alkaline solutions.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

12352201

To Order From a Quote