GW4869

SIGMA/D1692 - ≥90% (NMR)

Synonym: N,N′-Bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-3,3′-p-phenylene-bis-acrylamide dihydrochloride

CAS Number: 6823-69-4
Empirical Formula (Hill Notation): C₃₀H₂₈N₆O₂· 2HCl
Molecular Weight: 577.50
Linear Formula: C₃₀H₂₈N₆O₂· 2HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-D1692-5MG	5 mg	$261.00 1/EA	Add To Favorites
45-D1692-25MG	25 mg	$985.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D1692-25MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (NMR)
color	light yellow to yellow
form	powder
InChI	1S/C30H28N6O2.2ClH/c37-27(35-25-11-7-23(8-12-25)29-31-17-18-32-29)15-5-21-1-2-22(4-3-21)6-16-28(38)36-26-13-9-24(10-14-26)30-33-19-20-34-30;;/h1-16H,17-20H2,(H,31,32)(H,33,34)(H,35,37)(H,36,38);2*1H/b15-5-,16-6-;;
InChI key	NSFKAZDTKIKLKT-LOLTXFFGSA-N
mp	>300 °C
originator	GlaxoSmithKline
Quality Level	100
SMILES string	Cl.Cl.O=C(Nc1ccc(cc1)C2=NCCN2)C=C/c3ccc(C=C/C(=O)Nc4ccc(cc4)C5=NCCN5)cc3
solubility	DMSO: 0.2 mg/mL
storage condition	desiccated
	protect from light
storage temp.	2-8°C

Application:	GW4869 has been used: • as an inhibitor of neutral sphingomyelinase and exosome biogenesis • to analyse the effects of arsenic trioxide (ATO) treatment for hepatoma carcinoma HCCLM3 cells on ceramide production • to determine the contributions of p75 neurotrophin receptor (p75^NTR) and tropomyosin receptor kinase A (TrkA)- coupled pathways to nerve growth factor (NGF)-induced thermal hypersensitivity in rats
Biochem/physiol Actions:	A cell-permeable, potent, specific, non-competitive inhibitor of N-SMase (neutral sphingomyelinase)
Features and Benefits:	This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	GW4869 is a commonly used pharmacological agent, which inhibits exosome generation. It blocks ceramide-mediated inward budding of multivesicular bodies (MVBs) and the release of mature exosomes from MVBs. GW4869 exhibits cytotoxicity to phosphatidylserine-expressing myeloma cells. It inhibits the secretion of IFN (interferon)-α by plasmacytoid dendritic cells (pDCs).
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (NMR)
mp	>300 °C
Storage Temp.	2-8°C
UNSPSC	41121800

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